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These results with aged beagle dogs, whose brains, as noted above, have Aβ42 of identical amino acid sequence as Aβ42 in human brains and therefore the observations are likely applicable to humans, support the notion that translational intervention in MCI and AD individuals involving these two strategies, i.e., high-antioxidant-containing diets (such as one would experience with a Mediterranean diet) coupled with deliberative efforts to produce new synaptic connections (such as learning a new language, to play a new musical instrument, and/or to solve challenging puzzles) conceivably would decrease the neuropathology and rate of cognitive decline associated with both disorders